Bozoma Saint John doesn’t shrink away from the spotlight.

Saint John, 48, was Netflix’s first Black C-level executive as their chief marketing officer. She became Uber’s first chief branding officer tasked with rehabbing the rideshare company’s image. And she made headlines in 2016 when she shook up the stage at Apple’s annual conference despite not looking like a typical “Apple fan boy,” she says.

Saint John’s career moves are as as bold as her personal style. And she has what she considers some well-meaning but misguided advice to thank for that.

“An early manager told me never to wear red lipstick or red nail polish,” Saint John tells CNBC Make It when asked about the best career advice she’s ever gotten.

“She did it with good intention, like, ‘You walk into a room and you don’t want to be too bold. You don’t want people to make opinions of you before you even open your mouth,'” Saint John says.

But “that made me question my appearance in rooms. Being a Black woman who’s quite tall and bold in her wardrobe, I found that it really shrank me.”

Saint John says she decided to ignore that advice and flip it on its head to “be the most colorful, the boldest, the sharpest, the wittiest in a room, and feel very confident in it.”

“I’ve been able to be successful because I didn’t take that advice,” she says.

Saint John continues to go after big changes in her career, becoming a first-time CEO for her own hair and beauty brand, Eve by Boz, and most recently adding “reality TV star” to her resume a cast member of Bravo’s “Real Housewives of Beverly Hills” and as co-host of NBC’s “On Brand with Jimmy Fallon.”

And she wants you to go after your big career swings, too.

With people approaching a new year with new work goals, Saint John says it’s a good time as any to go after what you really want in your career. “That the pivot can happen any moment,” she says.

Here, Saint John draws on her own career and experience managing thousands to share the signs it’s time to quit a job, how to shape your professional brand, a major red flag when interviewing with companies, and more.

Amina AlTai has always been a high achiever.

As a child of immigrants, she was told to “keep your head down, work really hard, and if you do that, you’ll have everything you want,” she tells CNBC Make It.

Her early career looked “great on paper,” she says: AlTai opened her own marketing agency in her late 20s, and says she was “achieving all the milestones” of success.

At the same time, she was overworking herself to the point of illness, she says. One day, while driving to a client meeting, she got a call from her physician.

“My doctor called to say that if I don’t go to the hospital now, instead of going to work, I’ll be days away from multiple organ failure” due to severe anemia, AlTai says.

In hindsight, the moment was “such a wake-up call,” she says — but instead of heading straight for the hospital, AlTai first attended her client meeting.

She says she was subsequently diagnosed with celiac disease and Hashimoto’s thyroiditis, both of which were exacerbated by exhaustion.

“My workaholic tendencies and painful relationship to success were — quite literally — killing me,” AlTai, now 41, wrote in her recent book, “The Ambition Trap: How to Stop Chasing and Start Living.”

Today, AlTai is a leadership coach who teaches her clients how to protect their wellbeing and practice healthy ambition.

“So many of us are working ourselves into pain and suffering,” she says — but it doesn’t have to be that way. Here’s her advice for building a healthy mindset around ambition.

Though AlTai’s unhealthy relationship with ambition caused her to “crash and burn,” she says, it doesn’t mean that being driven is inherently a bad thing.

“I think ambition is neutral and natural,” she says. She defines it as “simply a desire for more life, a wish to grow, a wish to unfold.”

In AlTai’s view, people tend to experience ambition in two ways, she says: “painful” ambition and “purposeful” ambition.

Painful ambition, which AlTai defines as “the voracious desire to advance, regardless of the cost,” stems from a feeling of “not-enoughness,” she writes in “The Ambition Trap.” From a psychological perspective, painful ambition is based in emotional “core wounds” like rejection, abandonment, humiliation, betrayal and injustice, she says.

“If you build your ambition upon that, it’s going to be a bit of a house of cards,” AlTai says, “because we’re perpetually looking for the salve on the outside for the wound on the inside, and that never works.”

On the other hand, purposeful ambition “comes from a place of wholeness,” she says. People who practice purposeful ambition are driven by a desire to make a positive impact, AlTai says. They excel at collaborating with others, protect their needs and approach their mistakes with a growth mindset.

Self-awareness is the key to turning painful ambition into purposeful ambition, according to AlTai. She encourages her clients to journal about their thought patterns without self-judgement, taking note when…