Novo Nordisk stock falls as weight loss drug fails to beat Eli Lilly
The Novo Nordisk A/S headquarters in Bagsvaerd, Denmark, on Wednesday, Nov. 5, 2025.
Nichlas Pollier | Bloomberg | Getty Images
Novo Nordisk stock fell as much as 15% Monday after it said its next-generation weight loss drug didn’t meet its key goal of showing that it wasn’t inferior to Eli Lilly’s rival drug, in the latest blow to the Danish drugmaker, whose stock is trading at a multi-year low after a series of disappointing announcements.
The experimental drug, CagriSema, didn’t achieve its primary endpoint of demonstrating non-inferiority on weight loss when compared to Eli Lilly’s rival drug tirzepatide after 84 weeks, Novo said in a statement Monday morning.
Tirzepatide is the active ingredient in Lilly’s mega-blockbuster medicines Mounjaro and Zepbound, which have overtaken Novo Nordisk’s semaglutide, sold as Ozempic and Wegovy, in U.S. prescriptions.
Novo’s Copenhagen-listed shares were last seen down 14% at 259 Danish kroner, hitting their lowest level since June 2021.
Eli Lilly‘s stock rose 3.1% in premarket trading.
Novo Nordisk ADR’s are severely underperforming Eli Lilly shares.
Patients taking a 2.4 mg dose of CagriSema achieved a weight loss of 23% after 84 weeks compared to 25.5% with a 15 mg dose of tirzepatide, Novo said.
The trial was a so-called open-label trial, meaning participants knew what treatment they were receiving. Such a design can introduce bias in favor of a well-known product when it is compared to an investigational therapy, said Novo’s Chief Scientific Officer Martin Holst Lange, adding that he was “surprised” by the 25% weight loss seen with tirzepatide.
Lilly’s own studies have shown tirzepatide to result in a 20.2% weight loss over 72 weeks for people living with obesity or overweight.
Eli Lilly didn’t immediately respond to a CNBC request for comment.
Next-generation weight loss drugs
Novo filed CagriSema for approval from the U.S. Food and Drug Administration late last year, and a decision is expected by late 2026. It has high hopes for the drug, which combines semaglutide and cagrilintide, another hormone released in the pancreas that affects appetite.
Despite Monday’s disappointing results, Novo CEO Mike Doustdar remained upbeat about CagriSema’s potential.
“We strongly believe that CagriSema has, right now, the best weight efficacy than any product currently in the market,” he said.
Novo is exploring additional trials to test CagriSema, including higher-dose combinations, the company said.
“CagriSema has the potential to be the first GLP-1/amylin-combination product to reach the market for people living with obesity, documenting that cagrilintide adds to the existing benefits of semaglutide and offers clinically meaningful additive weight loss effects superior to what has been observed with GLP-1 biology alone,” said Novo’s Lange, adding that further trials would “assess the full weight-loss potential of CagriSema.”
However, the failure of CagiSema to meet non-inferiority…
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